Encapsulating Anti-Parasite Benzimidazole Drugs into Lipid-Coated Calcium Phosphate Nanoparticles to Efficiently Induce Skin Cancer Cell Apoptosis

Benzimidazole (BMZ) family of anti-worm drugs has been now repurposed as anti-cancer drugs. However, offering a general reformulation method for these is essential due to their hydrophobicity and low aqueous solubility. In this work, we developed approach load typical BMZ tiny nanocrystals within lipid-coated calcium phosphate (LCP) nanoparticles. drug-loaded LCP nanoparticles increased solubility in PBS by 100–200% significantly enhanced the efficacy treatment B16F0 melanoma cells. These drug-LCP induced much more cancer cell apoptosis, generated reactive oxygen species (ROS) inhibited Bcl-2 expression Moreover, caused morphological change extension disruption cells, reduced migration activity, representing high possibility inhibition tumor dissemination metastasis. Very advantageously, did not show any obvious toxicity, changes HEK293T healthy conclusion, drug-incorporated nanoformulations may be valuable nanomedicine that able inhibit primary tumors prevent with minimum side effects on cells tissues.